(6)-gingerol, 10-gingerol, 6-gingerol, gingerol
| Name | [6]-Gingerol | ||
| PubChem CID | 442793 | ||
| Molecular Weight | 294.4g/mol | ||
| Synonyms |
(6)-gingerol, 10-gingerol, 6-gingerol, gingerol |
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| Formula | C₁₇H₂₆O₄ | ||
| SMILES | CCCCCC(CC(=O)CCC1=CC(=C(C=C1)O)OC)O | ||
| InChI | 1S/C17H26O4/c1-3-4-5-6-14(18)12-15(19)9-7-13-8-10-16(20)17(11-13)21-2/h8,10-11,14,18,20H,3-7,9,12H2,1-2H3/t14-/m0/s1 | ||
| InChIKey | NLDDIKRKFXEWBK-AWEZNQCLSA-N | ||
| CAS Number | 23513-14-6 | ||
| ChEMBL ID | CHEMBL402978 | ||
| ChEBI ID | CHEBI:10136 | ||
| KEGG ID | C10462 | ||
| Toxicity | Organism | Test Type | Route(Dose) |
| rat | LD50 | intraperitoneal(165 mg/kg) | |
| mouse | LD50 | intraperitoneal(254 mg/kg) | |
| rat | LD50 | oral(322 mg/kg) | |
| Structure | 
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Download
2D
MOL
3D
MOL
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| Chineses Pinyin | PaoJiang | ||
| Use Part | Rhizome | ||
| Habitat | China | ||
| Flavor | Pungent | ||
| Meridian Tropism | Spleen, Stomach, Kidney | ||
| Species |
>Kingdom: Viridiplantae
-->Phylum: Streptophyta
-->Class: Equisetopsida
-->Order: Zingiberales
-->Family: Zingiberaceae
-->Genus: Zingiber
-->Species: Zingiber officinale
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| Chineses Pinyin | ShengJiang | ||
| Use Part | Fresh rhizome | ||
| Habitat | SiChuan, GuiZhou, HuBei, GuangDong, GuangXi | ||
| Flavor | Pungent | ||
| Meridian Tropism | Lung; Spleen; Stomach | ||
| Species |
>Kingdom: Viridiplantae
-->Phylum: Streptophyta
-->Class: Equisetopsida
-->Order: Zingiberales
-->Family: Zingiberaceae
-->Genus: Zingiber
-->Species: Zingiber officinale
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| Pair Name | [6]-Gingerol, Cisplatin | |||
| Partner Name | Cisplatin | |||
| Disease Info | [ICD-11: 2B72.Z] | Gastric cancer | Investigative | |
| Biological Phenomena | Induction-->Blockade of cell cycle in G0/G1 phase | |||
| Gene Regulation | Down-regulation | Expression | CCND1 | hsa595 |
| Down-regulation | Expression | CCNA2 | hsa890 | |
| Down-regulation | Expression | MMP9 | hsa4318 | |
| Down-regulation | Phosphorylation | PIK3CA | hsa5290 | |
| Down-regulation | Phosphorylation | AKT1 | hsa207 | |
| Up-regulation | Expression | CDKN1A | hsa1026 | |
| Up-regulation | Expression | PSMD9 | hsa5715 | |
| In Vitro Model | BGC-823 | Human papillomavirus-related cervical adenocarcinoma | Homo sapiens (Human) | CVCL_3360 |
| Result | [6]-Gingerol enhances the cisplatin sensitivity of gastric cancer cells through inhibition of proliferation and invasion via PI3K/AKT signaling pathway | |||
| Pair Name | [6]-Gingerol, Cisplatin | |||
| Partner Name | Cisplatin | |||
| Disease Info | [ICD-11: 2C73] | Ovarian cancer | Investigative | |
| Biological Phenomena | Inhibition-->Angiogenesis | |||
| Gene Regulation | Up-regulation | Expression | TP53 | hsa7157 |
| Up-regulation | Expression | CASP8 | hsa841 | |
| Up-regulation | Expression | BAX | hsa581 | |
| Up-regulation | Expression | APAF1 | hsa317 | |
| Down-regulation | Expression | VEGFA | hsa7422 | |
| Down-regulation | Expression | FLT1 | hsa2321 | |
| Down-regulation | Expression | KDR | hsa3791 | |
| Down-regulation | Expression | BCL2 | hsa596 | |
| In Vitro Model | OVCAR-3 | High grade ovarian serous adenocarcinoma | Homo sapiens (Human) | CVCL_0465 |
| Result | The findings of the present study demonstrated that the cisplatin and 6-gingerol combination is more effective in inducing apoptosis and suppressing the angiogenesis of ovarian cancer cells than using each drug alone. | |||
| Pair Name | [6]-Gingerol, Paclitaxel | |||
| Partner Name | Paclitaxel | |||
| Disease Info | [ICD-11: 2C60] | Breast cancer | Investigative | |
| Biological Phenomena | Inhibition-->Angiogenesis | |||
| Gene Regulation | Up-regulation | Expression | TP53 | hsa7157 |
| Down-regulation | Expression | BCL2 | hsa596 | |
| Up-regulation | Expression | BAX | hsa581 | |
| Up-regulation | Activity | CASP7 | hsa840 | |
| In Vitro Model | MCF-7 | Invasive breast carcinoma of no special type | Homo sapiens (Human) | CVCL_0031 |
| Result | Anticancer Efficacy of 6-Gingerol with Paclitaxel against Wild Type of Human Breast Adenocarcinoma | |||
| No. | Title | Href |
|---|---|---|
| 1 | [6]-Gingerol enhances the cisplatin sensitivity of gastric cancer cells through inhibition of proliferation and invasion via PI3K/AKT signaling pathway. Phytother Res. 2019 May;33(5):1353-1362. doi: 10.1002/ptr.6325. | Click |
| 2 | The inhibitory effect of 6-gingerol and cisplatin on ovarian cancer and antitumor activity: In silico, in vitro, and in vivo. Front Oncol. 2023 Mar 3;13:1098429. doi: 10.3389/fonc.2023.1098429. | Click |
| 3 | Anticancer Efficacy of 6-Gingerol with Paclitaxel against Wild Type of Human Breast Adenocarcinoma. Molecules. 2022 Apr 22;27(9):2693. doi: 10.3390/molecules27092693. | Click |
